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Samtidig brug af visse midler mod melancholy (fx SSRI og SNRI) øger risiko for alvorlig forgiftning. Dosis kan evt. stige efter behov. Ældre. Dosis bør nedsættes. Bemærk: Depottabletterne skal synkes hele. Depottabletterne må ikke tygges eller knuses. Depottablettens hårde kerne kan i nogle tilfælde udskilles med afføringen. Nedsat nyrefu